Spyre Therapeutics, Inc. (SYRE) · Insider trading

What Spyre Therapeutics's directors, officers and largest holders bought and sold themselves, from the Form 4 each of them files with the SEC within two business days of a trade. Open-market purchases and sales first: those are the trades somebody chose to make at the market price.

Bought, 12 months

0 insiders, 0 trades

Sold, 12 months

$442.98M

7 insiders, 9% under a plan

Net, 12 months

−$442.98M

bought less sold

Latest filing

2026-10-02

filings read to 2026-10-19

Bought and sold at the market, by month

Two years. Purchases above the line, sales below, in dollars.

Bought Sold Largest month: $405.18M

Who traded, two years

Insider	Bought	Sold	Trades	Last trade	Holds after
Harwin Peter EvanDirector	–	$399.66M	1	2026-06-23	–
Turtle CameronDirector, Chief Executive Officer	–	$11.37M	40	2026-10-01	551,940
Burrows Scott LChief Financial Officer	–	$9.42M	27	2026-10-01	86,662
Henderson Michael ThomasDirector	–	$7.95M	5	2026-06-22	68,606
Sloan SheldonChief Medical Officer	–	$7.35M	11	2026-07-01	1,834
King-Jones HeidySee Remarks	–	$5.11M	10	2026-10-01	31,378
Albers Jeffrey W.Director	–	$2.66M	5	2026-08-07	0

Open-market purchases and sales

Newest first. “Plan” marks a trade made under a 10b5-1 plan set up in advance.

Date	Insider	Trade	Shares	Price	Value	Holds after	Filing
2026-10-01	Burrows Scott LChief Financial Officer	Saleplan	600	89.07	$53,442	86,662	Form 4
2026-10-01	Burrows Scott LChief Financial Officer	Saleplan	1,500	90.27	$135,405	85,162	Form 4
2026-10-01	Burrows Scott LChief Financial Officer	Saleplan	2,100	91.92	$193,032	83,062	Form 4
2026-10-01	Burrows Scott LChief Financial Officer	Saleplan	3,071	92.95	$285,449	79,991	Form 4
2026-10-01	Burrows Scott LChief Financial Officer	Saleplan	229	93.57	$21,428	79,762	Form 4
2026-10-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	600	89.14	$53,484	551,940	Form 4
2026-10-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	2,683	90.10	$241,738	549,257	Form 4
2026-10-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	2,638	91.49	$241,351	546,619	Form 4
2026-10-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	3,989	92.31	$368,225	542,630	Form 4
2026-10-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	4,990	93.37	$465,916	537,640	Form 4
2026-10-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	100	93.91	$9,391	537,540	Form 4
2026-10-01	King-Jones HeidySee Remarks	Saleplan	400	89.24	$35,696	31,378	Form 4
2026-10-01	King-Jones HeidySee Remarks	Saleplan	16,605	90.35	$1.50M	14,773	Form 4
2026-10-01	King-Jones HeidySee Remarks	Saleplan	7,228	91.35	$660,278	7,545	Form 4
2026-10-01	King-Jones HeidySee Remarks	Saleplan	2,100	92.70	$194,670	5,445	Form 4
2026-10-01	King-Jones HeidySee Remarks	Saleplan	2,600	93.46	$242,996	2,845	Form 4
2026-09-30	Burrows Scott LChief Financial Officer	Saleplan	17,500	89.89	$1.57M	79,762	Form 4
2026-09-02	Burrows Scott LChief Financial Officer	Saleplan	18,232	89.35	$1.63M	79,762	Form 4
2026-09-02	King-Jones HeidySee Remarks	Saleplan	400	90.00	$36,000	2,845	Form 4
2026-09-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	2,500	86.36	$215,900	565,040	Form 4
2026-09-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	8,400	87.15	$732,060	556,640	Form 4
2026-09-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	3,700	88.06	$325,822	552,940	Form 4
2026-09-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	400	89.07	$35,628	552,540	Form 4
2026-09-01	Burrows Scott LChief Financial Officer	Saleplan	900	86.25	$77,625	104,594	Form 4
2026-09-01	Burrows Scott LChief Financial Officer	Saleplan	4,384	87.11	$381,890	100,210	Form 4
2026-09-01	Burrows Scott LChief Financial Officer	Saleplan	2,016	88.03	$177,468	98,194	Form 4
2026-09-01	Burrows Scott LChief Financial Officer	Saleplan	200	89.04	$17,808	97,994	Form 4
2026-09-01	King-Jones HeidySee Remarks	Saleplan	4,845	86.40	$418,608	25,999	Form 4
2026-09-01	King-Jones HeidySee Remarks	Saleplan	16,548	87.20	$1.44M	9,451	Form 4
2026-09-01	King-Jones HeidySee Remarks	Saleplan	6,206	88.17	$547,183	3,245	Form 4
2026-09-01	King-Jones HeidySee Remarks	Saleplan	400	89.38	$35,752	2,845	Form 4
2026-08-07	Albers Jeffrey W.Director	Saleplan	5,000	104.47	$522,350	0	Form 4
2026-08-07	Albers Jeffrey W.Director	Saleplanindirect	8,000	104.38	$835,040	19,360	Form 4
2026-08-07	Albers Jeffrey W.Director	Saleplanindirect	10,000	104.68	$1.05M	9,360	Form 4
2026-08-03	Turtle CameronDirector, Chief Executive Officer	Saleplan	800	93.97	$75,176	581,740	Form 4
2026-08-03	Turtle CameronDirector, Chief Executive Officer	Saleplan	7,157	95.10	$680,631	574,583	Form 4
2026-08-03	Turtle CameronDirector, Chief Executive Officer	Saleplan	5,635	95.93	$540,566	568,948	Form 4
2026-08-03	Turtle CameronDirector, Chief Executive Officer	Saleplan	1,392	96.82	$134,773	567,556	Form 4
2026-08-03	Turtle CameronDirector, Chief Executive Officer	Saleplan	16	97.46	$1,559	567,540	Form 4
2026-08-03	Burrows Scott LChief Financial Officer	Saleplan	5,100	95.21	$485,571	100,394	Form 4

59 more

2026-08-03	Burrows Scott LChief Financial Officer	Saleplan	2,300	96.30	$221,490	98,094	Form 4
2026-08-03	Burrows Scott LChief Financial Officer	Saleplan	100	97.10	$9,710	97,994	Form 4
2026-07-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	10,176	87.44	$889,789	587,364	Form 4
2026-07-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	4,234	88.12	$373,100	583,130	Form 4
2026-07-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	590	88.91	$52,457	582,540	Form 4
2026-07-01	Sloan SheldonChief Medical Officer	Saleplan	6,500	87.52	$568,880	1,834	Form 4
2026-07-01	Sloan SheldonChief Medical Officer	Saleplan	1,834	88.34	$162,016	0	Form 4
2026-07-01	Burrows Scott LChief Financial Officer	Saleplan	5,775	87.55	$505,601	99,719	Form 4
2026-07-01	Burrows Scott LChief Financial Officer	Saleplan	1,725	88.37	$152,438	97,994	Form 4
2026-06-25	Burrows Scott LChief Financial Officer	Sale	5,000	87.12	$435,600	107,994	Form 4
2026-06-25	Burrows Scott LChief Financial Officer	Sale	10,000	87.14	$871,400	97,994	Form 4
2026-06-23	Harwin Peter EvanDirectorwith Fairmount Healthcare Fund II L.P., Fairmount Funds Management LLC, Kiselak Tomas	Saleindirect	4,684,781	85.31	$399.66M	0	Form 4
2026-06-22	Henderson Michael ThomasDirector	Saleplan	20,000	100.00	$2.00M	68,606	Form 4
2026-06-03	Sloan SheldonChief Medical Officer	Saleplan	8,333	75.00	$624,975	0	Form 4
2026-06-01	Burrows Scott LChief Financial Officer	Saleplan	1,801	69.75	$125,620	103,693	Form 4
2026-06-01	Burrows Scott LChief Financial Officer	Saleplan	2,599	70.77	$183,931	101,094	Form 4
2026-06-01	Burrows Scott LChief Financial Officer	Saleplan	3,100	72.06	$223,386	97,994	Form 4
2026-06-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	3,557	69.40	$246,856	608,983	Form 4
2026-06-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	8,149	70.50	$574,504	600,834	Form 4
2026-06-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	3,294	71.38	$235,126	597,540	Form 4
2026-05-08	Henderson Michael ThomasDirector	Saleplan	2,404	72.57	$174,458	166,202	Form 4
2026-05-08	Henderson Michael ThomasDirector	Saleplan	33,513	73.72	$2.47M	132,689	Form 4
2026-05-08	Henderson Michael ThomasDirector	Saleplan	24,814	74.76	$1.86M	107,875	Form 4
2026-05-08	Henderson Michael ThomasDirector	Saleplan	19,269	75.35	$1.45M	88,606	Form 4
2026-05-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	5,300	69.54	$368,562	622,240	Form 4
2026-05-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	3,600	70.77	$254,772	618,640	Form 4
2026-05-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	1,000	71.76	$71,760	617,640	Form 4
2026-05-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	3,100	73.14	$226,734	614,540	Form 4
2026-05-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	1,700	74.23	$126,191	612,840	Form 4
2026-05-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	300	74.96	$22,488	612,540	Form 4
2026-05-01	Burrows Scott LChief Financial Officer	Saleplan	12,500	71.37	$892,125	97,994	Form 4
2026-05-01	Sloan SheldonChief Medical Officer	Saleplan	21,306	69.53	$1.48M	57,027	Form 4
2026-05-01	Sloan SheldonChief Medical Officer	Saleplan	19,656	70.61	$1.39M	37,371	Form 4
2026-05-01	Sloan SheldonChief Medical Officer	Saleplan	8,777	71.56	$628,082	28,594	Form 4
2026-05-01	Sloan SheldonChief Medical Officer	Saleplan	12,777	72.94	$931,954	15,817	Form 4
2026-05-01	Sloan SheldonChief Medical Officer	Saleplan	10,358	73.74	$763,799	5,459	Form 4
2026-05-01	Sloan SheldonChief Medical Officer	Saleplan	5,059	74.60	$377,401	400	Form 4
2026-05-01	Sloan SheldonChief Medical Officer	Saleplan	400	75.37	$30,148	0	Form 4
2026-04-01	Sloan SheldonChief Medical Officer	Saleplan	7,958	50.00	$397,900	0	Form 4
2026-04-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	12,344	49.20	$607,325	630,196	Form 4
2026-04-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	2,656	49.92	$132,588	627,540	Form 4
2026-04-01	Burrows Scott LChief Financial Officer	Saleplan	6,200	49.21	$305,102	99,294	Form 4
2026-04-01	Burrows Scott LChief Financial Officer	Saleplan	1,300	49.98	$64,974	97,994	Form 4
2026-03-03	Burrows Scott LChief Financial Officer	Saleplan	2,300	40.56	$93,288	98,194	Form 4
2026-03-03	Burrows Scott LChief Financial Officer	Saleplan	200	41.66	$8,332	97,994	Form 4
2026-03-02	Turtle CameronDirector, Chief Executive Officer	Saleplan	5,900	41.73	$246,207	651,640	Form 4
2026-03-02	Turtle CameronDirector, Chief Executive Officer	Saleplan	9,100	42.49	$386,659	642,540	Form 4
2026-02-02	Turtle CameronDirector, Chief Executive Officer	Saleplan	957	31.82	$30,452	671,583	Form 4
2026-02-02	Turtle CameronDirector, Chief Executive Officer	Saleplan	14,043	32.87	$461,593	657,540	Form 4
2026-01-02	Turtle CameronDirector, Chief Executive Officer	Saleplan	12,709	30.47	$387,243	674,198	Form 4
2026-01-02	Turtle CameronDirector, Chief Executive Officer	Saleplan	2,191	31.79	$69,652	672,007	Form 4
2026-01-02	Turtle CameronDirector, Chief Executive Officer	Saleplan	100	32.39	$3,239	671,907	Form 4
2025-12-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	10,995	28.73	$315,886	690,912	Form 4
2025-12-01	Turtle CameronDirector, Chief Executive Officer	Saleplan	4,005	29.83	$119,469	686,907	Form 4
2025-11-03	Turtle CameronDirector, Chief Executive Officer	Saleplan	28,155	23.13	$651,225	718,752	Form 4
2025-11-03	Turtle CameronDirector, Chief Executive Officer	Saleplan	16,845	23.66	$398,553	701,907	Form 4
2025-09-02	Burrows Scott LChief Financial Officer	Sale	18,428	16.26	$299,639	97,994	Form 4
2024-11-06	Albers Jeffrey W.Director	Saleplanindirect	6,700	36.76	$246,292	27,360	Form 4
2024-10-25	Albers Jeffrey W.Director	Saleplanindirect	300	36.43	$10,929	34,060	Form 4

Grants, exercises and other transactions

Pay, tax and paperwork rather than a choice to trade at the market price. Two years.

18 × option exercise2 × other1 × conversion

Show them

Date	Insider	What	Shares	Price	Holds after	Filing
2026-10-01	Burrows Scott LChief Financial Officer	Option exercise M	+7,500	14.50	87,262	Form 4
2026-10-01	King-Jones HeidySee Remarks	Option exercise M	+28,933	14.50	31,778	Form 4
2026-09-30	Burrows Scott LChief Financial Officer	Option exercise M	+17,500	14.50	97,262	Form 4
2026-09-02	King-Jones HeidySee Remarks	Option exercise M	+400	14.50	3,245	Form 4
2026-09-01	Burrows Scott LChief Financial Officer	Option exercise M	+7,500	14.50	105,494	Form 4
2026-09-01	King-Jones HeidySee Remarks	Option exercise M	+27,999	14.50	30,844	Form 4
2026-08-07	Albers Jeffrey W.Director	Option exercise M	+5,000	10.39	5,000	Form 4
2026-08-03	Burrows Scott LChief Financial Officer	Option exercise M	+7,500	14.50	105,494	Form 4
2026-07-01	Sloan SheldonChief Medical Officer	Option exercise M	+8,334	27.46	8,334	Form 4
2026-07-01	Burrows Scott LChief Financial Officer	Option exercise M	+7,500	14.50	105,494	Form 4
2026-06-25	Burrows Scott LChief Financial Officer	Option exercise M	+15,000	14.50	112,994	Form 4
2026-06-23	Harwin Peter EvanDirector	Conversion C	+666,680	–	4,684,781	Form 4
2026-06-03	Sloan SheldonChief Medical Officer	Option exercise M	+8,333	27.46	8,333	Form 4
2026-06-01	Burrows Scott LChief Financial Officer	Option exercise M	+7,500	14.50	105,494	Form 4
2026-05-01	Burrows Scott LChief Financial Officer	Option exercise M	+12,500	14.50	110,494	Form 4
2026-05-01	Sloan SheldonChief Medical Officer	Option exercise M	+78,333	27.46	78,333	Form 4
2026-04-01	Sloan SheldonChief Medical Officer	Option exercise M	+7,958	21.66	7,958	Form 4
2026-04-01	Burrows Scott LChief Financial Officer	Option exercise M	+7,500	14.50	105,494	Form 4
2026-03-03	Burrows Scott LChief Financial Officer	Option exercise M	+2,500	14.50	100,494	Form 4
2026-01-21	Henderson Michael ThomasDirector	Other J	+63,227	–	168,606	Form 4
2025-01-10	Henderson Michael ThomasDirector	Other J	+105,379	–	105,379	Form 4

How to read it

Buy, sale: Code P and S on the form: shares bought or sold in the market, at the market price. The other codes are mostly pay (a grant, an option exercised) or tax (shares the company withheld), and say little about what the insider thinks of the price.
Plan: A sale or purchase under a Rule 10b5-1 plan, set up in advance and running on its own schedule. Since April 2023 the form has a box for it. Much executive selling is planned and says more about diversifying than about the company.
Holds after: The shares the insider still held after the trade, in the form the trade was in (directly, or indirectly through a trust or a fund).
Value: Shares times the price the form reports, which is often an average over several fills on the day.

Read from the SEC's own quarterly data sets of Forms 3, 4 and 5, and from each day's filings since the last one. A correcting amendment replaces the lines it restates. Every row links to its filing. None of this is advice: insiders sell for many reasons, and buy for fewer.

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