Alnylam Pharmaceuticals Inc (ALNY) · Insider trading
What Alnylam Pharmaceuticals's directors, officers and largest holders bought and sold themselves, from the Form 4 each of them files with the SEC within two business days of a trade. Open-market purchases and sales first: those are the trades somebody chose to make at the market price.
Bought, 12 months
$0
0 insiders, 0 trades
Sold, 12 months
$43.95M
8 insiders, 63% under a plan
Net, 12 months
−$43.95M
bought less sold
Latest filing
2026-10-06
filings read to 2026-10-19
Who traded, two years
| Insider | Bought | Sold | Trades | Last trade | Holds after |
|---|---|---|---|---|---|
| Greenstreet YvonneDirector, Chief Executive Officer | – | $46.42M | 115 | 2026-03-04 | 98,493 |
| Garg PushkalEVP Chief R&D | – | $29.77M | 139 | 2026-03-05 | 20,443 |
| Ausiello Dennis ADirector | – | $13.73M | 11 | 2025-08-14 | 30,374 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | – | $13.45M | 134 | 2026-03-05 | 21,103 |
| Reitan Colleen FDirector | – | $8.43M | 17 | 2025-09-09 | 17,130 |
| Bonney Michael WDirector | – | $8.19M | 15 | 2025-08-18 | 16,804 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | – | $7.15M | 92 | 2026-03-04 | 64,159 |
| Tanguler TolgaEVP, Chief Commercial Officer | – | $5.86M | 85 | 2026-03-04 | 36,500 |
| Pyott David e IDirector | – | $3.37M | 6 | 2026-06-01 | 4,491 |
| Sharp Phillip ADirector | – | $3.09M | 1 | 2025-01-23 | 0 |
| McLaughlin MelissaChief Human Resources Officer | – | $1.27M | 14 | 2026-04-06 | 11,673 |
| Supran BryanEVP, CLO and Secretary | – | $398,855 | 1 | 2026-10-02 | 12,807 |
Open-market purchases and sales
Newest first. “Plan” marks a trade made under a 10b5-1 plan set up in advance.
| Date | Insider | Trade | Shares | Price | Value | Holds after | Filing |
|---|---|---|---|---|---|---|---|
| 2026-10-02 | Supran BryanEVP, CLO and Secretary | Sale | 1,758 | 226.88 | $398,855 | 12,807 | Form 4 |
| 2026-06-01 | Pyott David e IDirector | Saleplan | 921 | 297.71 | $274,191 | 4,491 | Form 4 |
| 2026-06-01 | Pyott David e IDirector | Saleplan | 1,175 | 298.91 | $351,219 | 3,316 | Form 4 |
| 2026-06-01 | Pyott David e IDirector | Saleplan | 1,222 | 299.87 | $366,441 | 2,094 | Form 4 |
| 2026-06-01 | Pyott David e IDirector | Saleplan | 495 | 300.72 | $148,856 | 1,599 | Form 4 |
| 2026-06-01 | Pyott David e IDirector | Saleplan | 17 | 302.65 | $5,145 | 1,582 | Form 4 |
| 2026-04-06 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 56 | 320.14 | $17,928 | 11,673 | Form 4 |
| 2026-04-06 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 909 | 329.76 | $299,752 | 10,764 | Form 4 |
| 2026-04-06 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 829 | 330.46 | $273,951 | 9,935 | Form 4 |
| 2026-04-06 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 293 | 331.89 | $97,244 | 9,642 | Form 4 |
| 2026-04-06 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 199 | 333.94 | $66,454 | 9,443 | Form 4 |
| 2026-04-02 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 265 | 316.61 | $83,902 | 13,088 | Form 4 |
| 2026-04-02 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 359 | 317.44 | $113,961 | 12,729 | Form 4 |
| 2026-04-02 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 209 | 318.47 | $66,560 | 12,520 | Form 4 |
| 2026-04-02 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 86 | 319.69 | $27,493 | 12,434 | Form 4 |
| 2026-04-02 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 147 | 320.62 | $47,131 | 12,287 | Form 4 |
| 2026-04-02 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 224 | 321.64 | $72,047 | 12,063 | Form 4 |
| 2026-04-02 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 245 | 322.86 | $79,101 | 11,818 | Form 4 |
| 2026-04-02 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 81 | 323.64 | $26,215 | 11,737 | Form 4 |
| 2026-04-02 | McLaughlin MelissaChief Human Resources Officer | Saleplan | 8 | 325.49 | $2,604 | 11,729 | Form 4 |
| 2026-03-05 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 124 | 321.81 | $39,904 | 21,103 | Form 4 |
| 2026-03-05 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 233 | 323.25 | $75,317 | 20,870 | Form 4 |
| 2026-03-05 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 148 | 324.60 | $48,041 | 20,722 | Form 4 |
| 2026-03-05 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 153 | 326.24 | $49,915 | 20,569 | Form 4 |
| 2026-03-05 | Garg PushkalEVP Chief R&D | Saleplan | 654 | 322.33 | $210,804 | 20,443 | Form 4 |
| 2026-03-05 | Garg PushkalEVP Chief R&D | Saleplan | 740 | 323.55 | $239,427 | 19,703 | Form 4 |
| 2026-03-05 | Garg PushkalEVP Chief R&D | Saleplan | 510 | 324.59 | $165,541 | 19,193 | Form 4 |
| 2026-03-05 | Garg PushkalEVP Chief R&D | Saleplan | 500 | 326.08 | $163,040 | 18,693 | Form 4 |
| 2026-03-04 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 29 | 319.03 | $9,252 | 21,831 | Form 4 |
| 2026-03-04 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 28 | 320.01 | $8,960 | 21,803 | Form 4 |
| 2026-03-04 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 59 | 320.81 | $18,928 | 21,744 | Form 4 |
| 2026-03-04 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 79 | 321.82 | $25,424 | 21,665 | Form 4 |
| 2026-03-04 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 96 | 323.01 | $31,009 | 21,569 | Form 4 |
| 2026-03-04 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 210 | 323.84 | $68,006 | 21,359 | Form 4 |
| 2026-03-04 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 75 | 324.88 | $24,366 | 21,284 | Form 4 |
| 2026-03-04 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 57 | 325.67 | $18,563 | 21,227 | Form 4 |
| 2026-03-04 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 106 | 319.03 | $33,817 | 36,500 | Form 4 |
| 2026-03-04 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 102 | 320.01 | $32,641 | 36,398 | Form 4 |
| 2026-03-04 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 215 | 320.81 | $68,974 | 36,183 | Form 4 |
| 2026-03-04 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 289 | 321.82 | $93,006 | 35,894 | Form 4 |
590 more
| 2026-03-04 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 350 | 323.01 | $113,054 | 35,544 | Form 4 |
| 2026-03-04 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 767 | 323.84 | $248,385 | 34,777 | Form 4 |
| 2026-03-04 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 272 | 324.88 | $88,367 | 34,505 | Form 4 |
| 2026-03-04 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 208 | 325.67 | $67,739 | 34,297 | Form 4 |
| 2026-03-04 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 114 | 319.03 | $36,369 | 64,159 | Form 4 |
| 2026-03-04 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 109 | 320.01 | $34,881 | 64,050 | Form 4 |
| 2026-03-04 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 230 | 320.81 | $73,786 | 63,820 | Form 4 |
| 2026-03-04 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 309 | 321.82 | $99,442 | 63,511 | Form 4 |
| 2026-03-04 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 374 | 323.01 | $120,806 | 63,137 | Form 4 |
| 2026-03-04 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 818 | 323.84 | $264,901 | 62,319 | Form 4 |
| 2026-03-04 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 291 | 324.88 | $94,540 | 62,028 | Form 4 |
| 2026-03-04 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 223 | 325.67 | $72,624 | 61,805 | Form 4 |
| 2026-03-04 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 135 | 319.03 | $43,069 | 98,493 | Form 4 |
| 2026-03-04 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 129 | 320.01 | $41,281 | 98,364 | Form 4 |
| 2026-03-04 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 274 | 320.81 | $87,902 | 98,090 | Form 4 |
| 2026-03-04 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 368 | 321.82 | $118,430 | 97,722 | Form 4 |
| 2026-03-04 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 444 | 323.01 | $143,416 | 97,278 | Form 4 |
| 2026-03-04 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 973 | 323.84 | $315,096 | 96,305 | Form 4 |
| 2026-03-04 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 345 | 324.88 | $112,084 | 95,960 | Form 4 |
| 2026-03-04 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 265 | 325.67 | $86,303 | 95,695 | Form 4 |
| 2026-03-04 | Garg PushkalEVP Chief R&D | Saleplan | 106 | 319.03 | $33,817 | 23,300 | Form 4 |
| 2026-03-04 | Garg PushkalEVP Chief R&D | Saleplan | 102 | 320.01 | $32,641 | 23,198 | Form 4 |
| 2026-03-04 | Garg PushkalEVP Chief R&D | Saleplan | 215 | 320.81 | $68,974 | 22,983 | Form 4 |
| 2026-03-04 | Garg PushkalEVP Chief R&D | Saleplan | 289 | 321.82 | $93,006 | 22,694 | Form 4 |
| 2026-03-04 | Garg PushkalEVP Chief R&D | Saleplan | 350 | 323.01 | $113,054 | 22,344 | Form 4 |
| 2026-03-04 | Garg PushkalEVP Chief R&D | Saleplan | 767 | 323.84 | $248,385 | 21,577 | Form 4 |
| 2026-03-04 | Garg PushkalEVP Chief R&D | Saleplan | 272 | 324.88 | $88,367 | 21,305 | Form 4 |
| 2026-03-04 | Garg PushkalEVP Chief R&D | Saleplan | 208 | 325.67 | $67,739 | 21,097 | Form 4 |
| 2026-03-03 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 289 | 316.55 | $91,483 | 23,223 | Form 4 |
| 2026-03-03 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 282 | 318.62 | $89,851 | 22,941 | Form 4 |
| 2026-03-03 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 722 | 320.51 | $231,408 | 22,219 | Form 4 |
| 2026-03-03 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 359 | 321.58 | $115,447 | 21,860 | Form 4 |
| 2026-03-03 | Garg PushkalEVP Chief R&D | Saleplan | 355 | 316.74 | $112,443 | 24,826 | Form 4 |
| 2026-03-03 | Garg PushkalEVP Chief R&D | Saleplan | 317 | 319.06 | $101,142 | 24,509 | Form 4 |
| 2026-03-03 | Garg PushkalEVP Chief R&D | Saleplan | 640 | 320.48 | $205,107 | 23,869 | Form 4 |
| 2026-03-03 | Garg PushkalEVP Chief R&D | Saleplan | 463 | 321.50 | $148,854 | 23,406 | Form 4 |
| 2026-03-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 200 | 323.62 | $64,724 | 105,227 | Form 4 |
| 2026-03-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 382 | 324.65 | $124,016 | 104,845 | Form 4 |
| 2026-03-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 1,098 | 325.63 | $357,542 | 103,747 | Form 4 |
| 2026-03-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 1,669 | 326.81 | $545,446 | 102,078 | Form 4 |
| 2026-03-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 1,399 | 327.67 | $458,410 | 100,679 | Form 4 |
| 2026-03-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 424 | 328.71 | $139,373 | 100,255 | Form 4 |
| 2026-03-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 722 | 329.71 | $238,051 | 99,533 | Form 4 |
| 2026-03-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 346 | 330.85 | $114,474 | 99,187 | Form 4 |
| 2026-03-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 399 | 331.93 | $132,440 | 98,788 | Form 4 |
| 2026-03-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 160 | 332.64 | $53,222 | 98,628 | Form 4 |
| 2026-03-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 47 | 323.62 | $15,210 | 38,157 | Form 4 |
| 2026-03-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 90 | 324.65 | $29,218 | 38,067 | Form 4 |
| 2026-03-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 258 | 325.63 | $84,013 | 37,809 | Form 4 |
| 2026-03-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 392 | 326.81 | $128,110 | 37,417 | Form 4 |
| 2026-03-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 329 | 327.67 | $107,803 | 37,088 | Form 4 |
| 2026-03-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 100 | 328.71 | $32,871 | 36,988 | Form 4 |
| 2026-03-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 170 | 329.71 | $56,051 | 36,818 | Form 4 |
| 2026-03-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 81 | 330.85 | $26,799 | 36,737 | Form 4 |
| 2026-03-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 94 | 331.93 | $31,201 | 36,643 | Form 4 |
| 2026-03-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 37 | 332.64 | $12,308 | 36,606 | Form 4 |
| 2026-03-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 47 | 323.62 | $15,210 | 25,063 | Form 4 |
| 2026-03-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 90 | 324.65 | $29,218 | 24,973 | Form 4 |
| 2026-03-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 258 | 325.63 | $84,013 | 24,715 | Form 4 |
| 2026-03-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 392 | 326.81 | $128,110 | 24,323 | Form 4 |
| 2026-03-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 329 | 327.67 | $107,803 | 23,994 | Form 4 |
| 2026-03-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 100 | 328.71 | $32,871 | 23,894 | Form 4 |
| 2026-03-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 170 | 329.71 | $56,051 | 23,724 | Form 4 |
| 2026-03-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 81 | 330.85 | $26,799 | 23,643 | Form 4 |
| 2026-03-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 94 | 331.93 | $31,201 | 23,549 | Form 4 |
| 2026-03-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 37 | 332.64 | $12,308 | 23,512 | Form 4 |
| 2026-03-02 | Garg PushkalEVP Chief R&D | Saleplan | 50 | 323.62 | $16,181 | 26,848 | Form 4 |
| 2026-03-02 | Garg PushkalEVP Chief R&D | Saleplan | 97 | 324.65 | $31,491 | 26,751 | Form 4 |
| 2026-03-02 | Garg PushkalEVP Chief R&D | Saleplan | 277 | 325.63 | $90,200 | 26,474 | Form 4 |
| 2026-03-02 | Garg PushkalEVP Chief R&D | Saleplan | 421 | 326.81 | $137,587 | 26,053 | Form 4 |
| 2026-03-02 | Garg PushkalEVP Chief R&D | Saleplan | 353 | 327.67 | $115,668 | 25,700 | Form 4 |
| 2026-03-02 | Garg PushkalEVP Chief R&D | Saleplan | 107 | 328.71 | $35,172 | 25,593 | Form 4 |
| 2026-03-02 | Garg PushkalEVP Chief R&D | Saleplan | 182 | 329.71 | $60,007 | 25,411 | Form 4 |
| 2026-03-02 | Garg PushkalEVP Chief R&D | Saleplan | 87 | 330.85 | $28,784 | 25,324 | Form 4 |
| 2026-03-02 | Garg PushkalEVP Chief R&D | Saleplan | 101 | 331.93 | $33,525 | 25,223 | Form 4 |
| 2026-03-02 | Garg PushkalEVP Chief R&D | Saleplan | 42 | 332.64 | $13,971 | 25,181 | Form 4 |
| 2026-03-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 65 | 323.62 | $21,035 | 66,414 | Form 4 |
| 2026-03-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 124 | 324.65 | $40,257 | 66,290 | Form 4 |
| 2026-03-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 356 | 325.63 | $115,924 | 65,934 | Form 4 |
| 2026-03-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 541 | 326.81 | $176,804 | 65,393 | Form 4 |
| 2026-03-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 454 | 327.67 | $148,762 | 64,939 | Form 4 |
| 2026-03-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 138 | 328.71 | $45,362 | 64,801 | Form 4 |
| 2026-03-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 234 | 329.71 | $77,152 | 64,567 | Form 4 |
| 2026-03-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 112 | 330.85 | $37,055 | 64,455 | Form 4 |
| 2026-03-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 129 | 331.93 | $42,819 | 64,326 | Form 4 |
| 2026-03-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 53 | 332.64 | $17,630 | 64,273 | Form 4 |
| 2026-02-27 | Garg PushkalEVP Chief R&D | Saleplan | 127 | 328.92 | $41,773 | 26,629 | Form 4 |
| 2026-02-27 | Garg PushkalEVP Chief R&D | Saleplan | 2,259 | 330.73 | $747,119 | 24,370 | Form 4 |
| 2026-02-27 | Garg PushkalEVP Chief R&D | Saleplan | 1,159 | 331.49 | $384,197 | 23,211 | Form 4 |
| 2026-02-27 | Garg PushkalEVP Chief R&D | Saleplan | 942 | 332.48 | $313,196 | 22,269 | Form 4 |
| 2026-02-27 | Garg PushkalEVP Chief R&D | Saleplan | 140 | 334.39 | $46,815 | 22,129 | Form 4 |
| 2026-02-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 2,041 | 331.96 | $677,530 | 21,264 | Form 4 |
| 2026-02-13 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 2,242 | 310.08 | $695,199 | 59,802 | Form 4 |
| 2026-02-13 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 1,959 | 310.08 | $607,447 | 23,305 | Form 4 |
| 2026-02-13 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 1,959 | 310.08 | $607,447 | 31,769 | Form 4 |
| 2026-02-13 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 6,958 | 310.08 | $2.16M | 85,662 | Form 4 |
| 2026-02-13 | Garg PushkalEVP Chief R&D | Sale | 2,242 | 310.08 | $695,199 | 24,848 | Form 4 |
| 2026-01-13 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 197 | 367.52 | $72,401 | 23,357 | Form 4 |
| 2026-01-13 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 562 | 368.76 | $207,243 | 22,795 | Form 4 |
| 2026-01-13 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 644 | 370.00 | $238,280 | 22,151 | Form 4 |
| 2026-01-13 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 485 | 371.24 | $180,051 | 21,666 | Form 4 |
| 2026-01-13 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 280 | 372.93 | $104,420 | 21,386 | Form 4 |
| 2026-01-13 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 122 | 374.33 | $45,668 | 21,264 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 39 | 353.95 | $13,804 | 25,025 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 42 | 355.16 | $14,917 | 24,983 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 41 | 356.09 | $14,600 | 24,942 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 96 | 357.17 | $34,288 | 24,846 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 123 | 358.18 | $44,056 | 24,723 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 85 | 359.14 | $30,527 | 24,638 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 155 | 360.22 | $55,834 | 24,483 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 98 | 361.45 | $35,422 | 24,385 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 73 | 362.38 | $26,454 | 24,312 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 47 | 363.55 | $17,087 | 24,265 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 199 | 364.83 | $72,601 | 24,066 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 220 | 365.56 | $80,423 | 23,846 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 50 | 366.41 | $18,320 | 23,796 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 41 | 367.40 | $15,063 | 23,755 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 92 | 368.62 | $33,913 | 23,663 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 40 | 369.48 | $14,779 | 23,623 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 19 | 370.87 | $7,047 | 23,604 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 2 | 372.46 | $745 | 23,602 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 14 | 374.44 | $5,242 | 23,588 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 19 | 375.65 | $7,137 | 23,569 | Form 4 |
| 2026-01-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 15 | 377.82 | $5,667 | 23,554 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 39 | 353.95 | $13,804 | 31,199 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 42 | 355.16 | $14,917 | 31,157 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 41 | 356.09 | $14,600 | 31,116 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 96 | 357.17 | $34,288 | 31,020 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 123 | 358.18 | $44,056 | 30,897 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 85 | 359.14 | $30,527 | 30,812 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 155 | 360.22 | $55,834 | 30,657 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 98 | 361.45 | $35,422 | 30,559 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 73 | 362.38 | $26,454 | 30,486 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 47 | 363.55 | $17,087 | 30,439 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 199 | 364.83 | $72,601 | 30,240 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 220 | 365.56 | $80,423 | 30,020 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 50 | 366.41 | $18,320 | 29,970 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 41 | 367.40 | $15,063 | 29,929 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 92 | 368.62 | $33,913 | 29,837 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 40 | 369.48 | $14,779 | 29,797 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 19 | 370.87 | $7,047 | 29,778 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 2 | 372.46 | $745 | 29,776 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 14 | 374.44 | $5,242 | 29,762 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 19 | 375.65 | $7,137 | 29,743 | Form 4 |
| 2026-01-12 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 15 | 377.82 | $5,667 | 29,728 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 72 | 353.95 | $25,484 | 60,173 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 78 | 355.16 | $27,702 | 60,095 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 76 | 356.09 | $27,063 | 60,019 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 176 | 357.17 | $62,862 | 59,843 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 226 | 358.18 | $80,949 | 59,617 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 156 | 359.14 | $56,026 | 59,461 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 284 | 360.22 | $102,302 | 59,177 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 181 | 361.45 | $65,422 | 58,996 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 135 | 362.38 | $48,921 | 58,861 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 87 | 363.55 | $31,629 | 58,774 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 365 | 364.83 | $133,163 | 58,409 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 405 | 365.56 | $148,052 | 58,004 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 92 | 366.41 | $33,710 | 57,912 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 76 | 367.40 | $27,922 | 57,836 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 170 | 368.62 | $62,665 | 57,666 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 73 | 369.48 | $26,972 | 57,593 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 36 | 370.87 | $13,351 | 57,557 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 6 | 372.46 | $2,235 | 57,551 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 25 | 374.44 | $9,361 | 57,526 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 34 | 375.65 | $12,772 | 57,492 | Form 4 |
| 2026-01-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 27 | 377.82 | $10,201 | 57,465 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 247 | 353.95 | $87,426 | 87,741 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 269 | 355.16 | $95,538 | 87,472 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 263 | 356.09 | $93,652 | 87,209 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 607 | 357.17 | $216,802 | 86,602 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 778 | 358.18 | $278,664 | 85,824 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 537 | 359.14 | $192,858 | 85,287 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 980 | 360.22 | $353,016 | 84,307 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 624 | 361.45 | $225,545 | 83,683 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 464 | 362.38 | $168,144 | 83,219 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 301 | 363.55 | $109,429 | 82,918 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 1,259 | 364.83 | $459,321 | 81,659 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 1,395 | 365.56 | $509,956 | 80,264 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 316 | 366.41 | $115,786 | 79,948 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 261 | 367.40 | $95,891 | 79,687 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 584 | 368.62 | $215,274 | 79,103 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 253 | 369.48 | $93,478 | 78,850 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 118 | 370.87 | $43,763 | 78,732 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 21 | 372.46 | $7,822 | 78,711 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 88 | 374.44 | $32,951 | 78,623 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 118 | 375.65 | $44,327 | 78,505 | Form 4 |
| 2026-01-12 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 94 | 377.82 | $35,515 | 78,411 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 39 | 353.95 | $13,804 | 23,982 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 42 | 355.16 | $14,917 | 23,940 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 41 | 356.09 | $14,600 | 23,899 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 96 | 357.17 | $34,288 | 23,803 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 123 | 358.18 | $44,056 | 23,680 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 85 | 359.14 | $30,527 | 23,595 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 155 | 360.22 | $55,834 | 23,440 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 98 | 361.45 | $35,422 | 23,342 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 73 | 362.38 | $26,454 | 23,269 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 47 | 363.55 | $17,087 | 23,222 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 199 | 364.83 | $72,601 | 23,023 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 220 | 365.56 | $80,423 | 22,803 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 50 | 366.41 | $18,320 | 22,753 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 41 | 367.40 | $15,063 | 22,712 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 92 | 368.62 | $33,913 | 22,620 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 40 | 369.48 | $14,779 | 22,580 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 18 | 370.87 | $6,676 | 22,562 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 3 | 372.46 | $1,117 | 22,559 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 14 | 374.44 | $5,242 | 22,545 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 19 | 375.65 | $7,137 | 22,526 | Form 4 |
| 2026-01-12 | Garg PushkalEVP Chief R&D | Sale | 15 | 377.82 | $5,667 | 22,511 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 8,168 | 449.00 | $3.67M | 25,224 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 96 | 450.09 | $43,209 | 25,128 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 129 | 451.51 | $58,245 | 24,999 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 368 | 455.24 | $167,528 | 24,631 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 364 | 456.25 | $166,075 | 24,267 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 262 | 457.39 | $119,836 | 24,005 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 794 | 458.41 | $363,978 | 23,211 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 622 | 459.89 | $286,052 | 22,589 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 707 | 460.84 | $325,814 | 21,882 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 323 | 461.96 | $149,213 | 21,559 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Saleplan | 295 | 463.08 | $136,609 | 21,264 | Form 4 |
| 2025-11-13 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 654 | 447.73 | $292,815 | 74,755 | Form 4 |
| 2025-11-13 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 1,013 | 448.76 | $454,594 | 73,742 | Form 4 |
| 2025-11-13 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 1,477 | 450.02 | $664,680 | 72,265 | Form 4 |
| 2025-11-13 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 2,218 | 450.69 | $999,630 | 70,047 | Form 4 |
| 2025-11-13 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 1,702 | 451.94 | $769,202 | 68,345 | Form 4 |
| 2025-11-13 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 1,599 | 452.85 | $724,107 | 66,746 | Form 4 |
| 2025-11-13 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 881 | 453.99 | $399,965 | 65,865 | Form 4 |
| 2025-11-13 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 195 | 454.69 | $88,665 | 65,670 | Form 4 |
| 2025-11-13 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 261 | 456.03 | $119,024 | 65,409 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 711 | 448.07 | $318,578 | 80,348 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 2,132 | 449.15 | $957,588 | 78,216 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 453 | 450.17 | $203,927 | 77,763 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 1,255 | 451.16 | $566,206 | 76,508 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 1,210 | 452.43 | $547,440 | 75,298 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 1,069 | 453.52 | $484,813 | 74,229 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 1,960 | 454.84 | $891,486 | 72,269 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 3,406 | 455.56 | $1.55M | 68,863 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 2,420 | 456.64 | $1.11M | 66,443 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 604 | 457.71 | $276,457 | 65,839 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Saleplan | 430 | 458.42 | $197,121 | 65,409 | Form 4 |
| 2025-10-03 | Garg PushkalEVP Chief R&D | Saleplan | 682 | 449.99 | $306,893 | 22,561 | Form 4 |
| 2025-10-03 | Garg PushkalEVP Chief R&D | Saleplan | 810 | 450.63 | $365,010 | 21,751 | Form 4 |
| 2025-10-03 | Garg PushkalEVP Chief R&D | Saleplan | 898 | 451.76 | $405,680 | 20,853 | Form 4 |
| 2025-10-03 | Garg PushkalEVP Chief R&D | Saleplan | 417 | 453.51 | $189,114 | 20,436 | Form 4 |
| 2025-10-03 | Garg PushkalEVP Chief R&D | Saleplan | 215 | 454.37 | $97,690 | 20,221 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 115 | 446.53 | $51,351 | 26,065 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 56 | 447.92 | $25,084 | 26,009 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 180 | 448.77 | $80,779 | 25,829 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 249 | 449.79 | $111,998 | 25,580 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 541 | 450.81 | $243,888 | 25,039 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 332 | 451.86 | $150,018 | 24,707 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 668 | 452.69 | $302,397 | 24,039 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 329 | 453.77 | $149,290 | 23,710 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 244 | 454.84 | $110,981 | 23,466 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 73 | 455.82 | $33,275 | 23,393 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 147 | 457.43 | $67,242 | 23,246 | Form 4 |
| 2025-10-02 | Garg PushkalEVP Chief R&D | Saleplan | 3 | 457.64 | $1,373 | 23,243 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 96 | 446.53 | $42,867 | 27,576 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 47 | 447.92 | $21,052 | 27,529 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 150 | 448.77 | $67,316 | 27,379 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 207 | 449.79 | $93,107 | 27,172 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 449 | 450.81 | $202,414 | 26,723 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 276 | 451.86 | $124,713 | 26,447 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 555 | 452.69 | $251,243 | 25,892 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 273 | 453.77 | $123,879 | 25,619 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 203 | 454.84 | $92,333 | 25,416 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 60 | 455.82 | $27,349 | 25,356 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 122 | 457.43 | $55,806 | 25,234 | Form 4 |
| 2025-10-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 3 | 457.64 | $1,373 | 25,231 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 55 | 446.53 | $24,559 | 28,788 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 27 | 447.92 | $12,094 | 28,761 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 86 | 448.77 | $38,594 | 28,675 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 119 | 449.79 | $53,525 | 28,556 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 260 | 450.81 | $117,211 | 28,296 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 159 | 451.86 | $71,846 | 28,137 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 319 | 452.69 | $144,408 | 27,818 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 157 | 453.77 | $71,242 | 27,661 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 117 | 454.84 | $53,216 | 27,544 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 35 | 455.82 | $15,954 | 27,509 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 70 | 457.43 | $32,020 | 27,439 | Form 4 |
| 2025-10-02 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 1 | 457.64 | $458 | 27,438 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 350 | 446.53 | $156,286 | 73,983 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 171 | 447.92 | $76,594 | 73,812 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 548 | 448.77 | $245,926 | 73,264 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 758 | 449.79 | $340,941 | 72,506 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 1,642 | 450.81 | $740,230 | 70,864 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 1,010 | 451.86 | $456,379 | 69,854 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 2,029 | 452.69 | $918,508 | 67,825 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 999 | 453.77 | $453,316 | 66,826 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 741 | 454.84 | $337,036 | 66,085 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 221 | 455.82 | $100,736 | 65,864 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 446 | 457.43 | $204,014 | 65,418 | Form 4 |
| 2025-10-02 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 9 | 457.64 | $4,119 | 65,409 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 150 | 446.53 | $66,980 | 57,723 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 73 | 447.92 | $32,698 | 57,650 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 234 | 448.77 | $105,012 | 57,416 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 324 | 449.79 | $145,732 | 57,092 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 704 | 450.81 | $317,370 | 56,388 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 432 | 451.86 | $195,204 | 55,956 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 869 | 452.69 | $393,388 | 55,087 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 428 | 453.77 | $194,214 | 54,659 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 317 | 454.84 | $144,184 | 54,342 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 95 | 455.82 | $43,303 | 54,247 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 191 | 457.43 | $87,369 | 54,056 | Form 4 |
| 2025-10-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 4 | 457.64 | $1,831 | 54,052 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 1,645 | 457.44 | $752,489 | 17,130 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 1,888 | 458.86 | $866,328 | 15,242 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 1,403 | 459.73 | $645,001 | 13,839 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 473 | 460.71 | $217,916 | 13,366 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 2,290 | 461.92 | $1.06M | 11,076 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 1,652 | 463.00 | $764,876 | 9,424 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 799 | 464.36 | $371,024 | 8,625 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 222 | 471.25 | $104,618 | 8,403 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 823 | 472.82 | $389,131 | 7,580 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 838 | 474.22 | $397,396 | 6,742 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 951 | 474.85 | $451,582 | 5,791 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 972 | 476.31 | $462,973 | 4,819 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 1,183 | 477.47 | $564,847 | 3,636 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 1,450 | 478.67 | $694,072 | 2,186 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 1,386 | 479.55 | $664,656 | 800 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Saleplan | 25 | 480.98 | $12,024 | 775 | Form 4 |
| 2025-08-29 | Tanguler TolgaEVP, Chief Commercial Officer | Saleplan | 195 | 445.53 | $86,878 | 29,271 | Form 4 |
| 2025-08-29 | Tanguler TolgaEVP, Chief Commercial Officer | Saleplan | 899 | 446.98 | $401,835 | 28,372 | Form 4 |
| 2025-08-29 | Tanguler TolgaEVP, Chief Commercial Officer | Saleplan | 1,289 | 448.05 | $577,536 | 27,083 | Form 4 |
| 2025-08-29 | Tanguler TolgaEVP, Chief Commercial Officer | Saleplan | 681 | 449.54 | $306,137 | 26,402 | Form 4 |
| 2025-08-29 | Tanguler TolgaEVP, Chief Commercial Officer | Saleplan | 266 | 451.52 | $120,104 | 26,136 | Form 4 |
| 2025-08-29 | Tanguler TolgaEVP, Chief Commercial Officer | Saleplan | 144 | 452.49 | $65,159 | 25,992 | Form 4 |
| 2025-08-19 | Garg PushkalEVP Chief R&D | Saleplan | 276 | 455.41 | $125,693 | 21,400 | Form 4 |
| 2025-08-19 | Garg PushkalEVP Chief R&D | Saleplan | 338 | 457.26 | $154,554 | 21,062 | Form 4 |
| 2025-08-19 | Garg PushkalEVP Chief R&D | Saleplan | 231 | 458.27 | $105,860 | 20,831 | Form 4 |
| 2025-08-19 | Garg PushkalEVP Chief R&D | Saleplan | 260 | 459.59 | $119,493 | 20,571 | Form 4 |
| 2025-08-19 | Garg PushkalEVP Chief R&D | Saleplan | 305 | 461.01 | $140,608 | 20,266 | Form 4 |
| 2025-08-19 | Garg PushkalEVP Chief R&D | Saleplan | 45 | 461.74 | $20,778 | 20,221 | Form 4 |
| 2025-08-18 | Bonney Michael WDirector | Saleplan | 11,250 | 450.00 | $5.06M | 16,804 | Form 4 |
| 2025-08-18 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 39 | 447.98 | $17,471 | 24,076 | Form 4 |
| 2025-08-18 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 90 | 449.92 | $40,493 | 23,986 | Form 4 |
| 2025-08-18 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 39 | 450.92 | $17,586 | 23,947 | Form 4 |
| 2025-08-18 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 103 | 451.99 | $46,555 | 23,844 | Form 4 |
| 2025-08-18 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 329 | 452.96 | $149,024 | 23,515 | Form 4 |
| 2025-08-18 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 543 | 454.04 | $246,544 | 22,972 | Form 4 |
| 2025-08-18 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 241 | 454.84 | $109,616 | 22,731 | Form 4 |
| 2025-08-18 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Sale | 12 | 455.82 | $5,470 | 22,719 | Form 4 |
| 2025-08-18 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 194 | 447.98 | $86,908 | 63,006 | Form 4 |
| 2025-08-18 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 450 | 449.92 | $202,464 | 62,556 | Form 4 |
| 2025-08-18 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 195 | 450.92 | $87,929 | 62,361 | Form 4 |
| 2025-08-18 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 514 | 451.99 | $232,323 | 61,847 | Form 4 |
| 2025-08-18 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 1,646 | 452.96 | $745,572 | 60,201 | Form 4 |
| 2025-08-18 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 2,716 | 454.04 | $1.23M | 57,485 | Form 4 |
| 2025-08-18 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 1,204 | 454.84 | $547,627 | 56,281 | Form 4 |
| 2025-08-18 | Greenstreet YvonneDirector, Chief Executive Officer | Sale | 60 | 455.82 | $27,349 | 56,221 | Form 4 |
| 2025-08-18 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 63 | 447.98 | $28,223 | 52,332 | Form 4 |
| 2025-08-18 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 147 | 449.92 | $66,138 | 52,185 | Form 4 |
| 2025-08-18 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 63 | 450.92 | $28,408 | 52,122 | Form 4 |
| 2025-08-18 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 168 | 451.99 | $75,934 | 51,954 | Form 4 |
| 2025-08-18 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 536 | 452.96 | $242,787 | 51,418 | Form 4 |
| 2025-08-18 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 886 | 454.04 | $402,279 | 50,532 | Form 4 |
| 2025-08-18 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 392 | 454.84 | $178,297 | 50,140 | Form 4 |
| 2025-08-18 | Poulton Jeffrey V.EVP, Chief Financial Officer | Sale | 19 | 455.82 | $8,661 | 50,121 | Form 4 |
| 2025-08-18 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 39 | 447.98 | $17,471 | 30,823 | Form 4 |
| 2025-08-18 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 90 | 449.92 | $40,493 | 30,733 | Form 4 |
| 2025-08-18 | Tanguler TolgaEVP, Chief Commercial Officer | Sale | 39 | 450.92 | $17,586 | 30,694 | Form 4 |
And 230 older ones, each in its filing at the SEC.
Grants, exercises and other transactions
Pay, tax and paperwork rather than a choice to trade at the market price. Two years.
68 × grant or award37 × option exercise2 × gift1 × shares withheld for tax
Show them
| Date | Insider | What | Shares | Price | Holds after | Filing |
|---|---|---|---|---|---|---|
| 2026-09-19 | Greenstreet YvonneDirector, Chief Executive Officer | Grant or award A | +107 | – | 95,802 | Form 4 |
| 2026-06-01 | Pyott David e IDirector | Option exercise M | +3,830 | – | 5,412 | Form 4 |
| 2026-05-20 | Arbuckle Stuart ADirector | Grant or award A | +671 | – | 671 | Form 4 |
| 2026-05-20 | Ausiello Dennis ADirector | Grant or award A | +671 | – | 1,582 | Form 4 |
| 2026-05-20 | Brandicourt OlivierDirector | Grant or award A | +671 | – | 1,446 | Form 4 |
| 2026-05-20 | Hamburg Margaret ADirector | Grant or award A | +671 | – | 1,582 | Form 4 |
| 2026-05-20 | Kellogg Peter NDirector | Grant or award A | +671 | – | 1,446 | Form 4 |
| 2026-05-20 | Pyott David e IDirector | Grant or award A | +671 | – | 1,582 | Form 4 |
| 2026-05-20 | Reitan Colleen FDirector | Grant or award A | +671 | – | 1,446 | Form 4 |
| 2026-05-20 | Schulman Amy WDirector | Grant or award A | +838 | – | 24,049 | Form 4 |
| 2026-05-20 | Sigal Charles ElliottDirector | Grant or award A | +671 | – | 1,446 | Form 4 |
| 2026-05-13 | Schulman Amy WDirector | Option exercise M | +11,250 | 70.20 | 23,211 | Form 4 |
| 2026-03-02 | Greenstreet YvonneDirector, Chief Executive Officer | Grant or award A | +13,844 | – | 105,427 | Form 4 |
| 2026-03-02 | Supran BryanEVP, CLO and Secretary | Grant or award A | +1,539 | – | 14,565 | Form 4 |
| 2026-03-02 | Tanguler TolgaEVP, Chief Commercial Officer | Grant or award A | +4,769 | – | 38,204 | Form 4 |
| 2026-03-02 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Grant or award A | +3,688 | – | 25,110 | Form 4 |
| 2026-03-02 | Garg PushkalEVP Chief R&D | Grant or award A | +4,769 | – | 26,898 | Form 4 |
| 2026-03-02 | Poulton Jeffrey V.EVP, Chief Financial Officer | Grant or award A | +4,769 | – | 66,479 | Form 4 |
| 2026-02-27 | Garg PushkalEVP Chief R&D | Option exercise M | +1,908 | – | 26,756 | Form 4 |
| 2026-02-27 | Tanguler TolgaEVP, Chief Commercial Officer | Option exercise M | +1,666 | – | 33,435 | Form 4 |
| 2026-02-27 | Poulton Jeffrey V.EVP, Chief Financial Officer | Option exercise M | +1,908 | – | 61,710 | Form 4 |
| 2026-02-27 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +5,921 | – | 91,583 | Form 4 |
| 2026-02-23 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Grant or award A | +158 | – | 21,422 | Form 4 |
| 2026-02-12 | Poulton Jeffrey V.EVP, Chief Financial Officer | Grant or award A | +4,579 | – | 62,044 | Form 4 |
| 2026-02-12 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Grant or award A | +4,000 | – | 25,264 | Form 4 |
| 2026-02-12 | Tanguler TolgaEVP, Chief Commercial Officer | Grant or award A | +4,000 | – | 33,728 | Form 4 |
| 2026-02-12 | Greenstreet YvonneDirector, Chief Executive Officer | Grant or award A | +14,209 | – | 92,620 | Form 4 |
| 2026-02-12 | Garg PushkalEVP Chief R&D | Grant or award A | +4,579 | – | 27,090 | Form 4 |
| 2026-01-11 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Grant or award A | +3,800 | – | 25,064 | Form 4 |
| 2026-01-11 | Tanguler TolgaEVP, Chief Commercial Officer | Grant or award A | +3,800 | – | 31,238 | Form 4 |
| 2026-01-11 | Poulton Jeffrey V.EVP, Chief Financial Officer | Grant or award A | +6,193 | – | 60,245 | Form 4 |
| 2026-01-11 | Greenstreet YvonneDirector, Chief Executive Officer | Grant or award A | +19,003 | – | 87,988 | Form 4 |
| 2026-01-11 | Garg PushkalEVP Chief R&D | Grant or award A | +3,800 | – | 24,021 | Form 4 |
| 2025-11-26 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +839 | 119.13 | 66,248 | Form 4 |
| 2025-11-26 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +2,352 | 85.00 | 68,600 | Form 4 |
| 2025-11-26 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +847 | 118.05 | 69,447 | Form 4 |
| 2025-11-26 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +659 | 151.59 | 70,106 | Form 4 |
| 2025-11-26 | Greenstreet YvonneDirector, Chief Executive Officer | Shares withheld for tax F | −1,121 | 445.12 | 68,985 | Form 4 |
| 2025-11-17 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Option exercise M | +8,161 | 119.13 | 33,392 | Form 4 |
| 2025-11-13 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +10,000 | 119.13 | 75,409 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +650 | 42.22 | 66,059 | Form 4 |
| 2025-11-12 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +15,000 | 119.13 | 81,059 | Form 4 |
| 2025-10-01 | Garg PushkalEVP Chief R&D | Grant or award A | +3,108 | – | 23,329 | Form 4 |
| 2025-10-01 | Garg PushkalEVP Chief R&D | Grant or award A | +2,851 | – | 26,180 | Form 4 |
| 2025-10-01 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Grant or award A | +2,102 | – | 24,821 | Form 4 |
| 2025-10-01 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Grant or award A | +2,851 | – | 27,672 | Form 4 |
| 2025-10-01 | Tanguler TolgaEVP, Chief Commercial Officer | Grant or award A | +2,851 | – | 28,843 | Form 4 |
| 2025-10-01 | Greenstreet YvonneDirector, Chief Executive Officer | Grant or award A | +3,860 | – | 60,081 | Form 4 |
| 2025-10-01 | Greenstreet YvonneDirector, Chief Executive Officer | Grant or award A | +14,252 | – | 74,333 | Form 4 |
| 2025-10-01 | Poulton Jeffrey V.EVP, Chief Financial Officer | Grant or award A | +3,108 | – | 53,229 | Form 4 |
| 2025-10-01 | Poulton Jeffrey V.EVP, Chief Financial Officer | Grant or award A | +4,644 | – | 57,873 | Form 4 |
| 2025-10-01 | Supran BryanEVP, CLO and Secretary | Grant or award A | +13,026 | – | 13,026 | Form 4 |
| 2025-09-09 | Reitan Colleen FDirector | Option exercise M | +18,000 | 100.65 | 18,775 | Form 4 |
| 2025-08-18 | Bonney Michael WDirector | Option exercise M | +11,250 | 70.20 | 28,054 | Form 4 |
| 2025-08-15 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Grant or award A | +2,851 | – | 24,115 | Form 4 |
| 2025-08-15 | Greenstreet YvonneDirector, Chief Executive Officer | Grant or award A | +14,252 | – | 63,200 | Form 4 |
| 2025-08-15 | Poulton Jeffrey V.EVP, Chief Financial Officer | Grant or award A | +4,644 | – | 52,395 | Form 4 |
| 2025-08-15 | Tanguler TolgaEVP, Chief Commercial Officer | Grant or award A | +2,851 | – | 30,862 | Form 4 |
| 2025-08-15 | Garg PushkalEVP Chief R&D | Grant or award A | +2,851 | – | 23,072 | Form 4 |
| 2025-08-14 | Ausiello Dennis ADirector | Option exercise M | +9,000 | 72.01 | 9,911 | Form 4 |
| 2025-08-14 | Ausiello Dennis ADirector | Option exercise M | +5,153 | 128.31 | 15,064 | Form 4 |
| 2025-08-14 | Ausiello Dennis ADirector | Option exercise M | +4,581 | 148.77 | 19,645 | Form 4 |
| 2025-08-14 | Ausiello Dennis ADirector | Option exercise M | +5,228 | 151.22 | 24,873 | Form 4 |
| 2025-08-14 | Ausiello Dennis ADirector | Option exercise M | +4,032 | 171.95 | 28,905 | Form 4 |
| 2025-08-14 | Ausiello Dennis ADirector | Option exercise M | +3,454 | 189.87 | 32,359 | Form 4 |
| 2025-07-01 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Grant or award A | +7,763 | – | 21,264 | Form 4 |
| 2025-06-02 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +12,080 | 119.13 | 61,028 | Form 4 |
| 2025-06-02 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +7,217 | 118.05 | 68,245 | Form 4 |
| 2025-05-30 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +12,081 | 119.13 | 61,029 | Form 4 |
| 2025-05-30 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +19,559 | 118.05 | 80,588 | Form 4 |
| 2025-05-16 | Greenstreet YvonneDirector, Chief Executive Officer | Gift G | −8,376 | – | 48,948 | Form 4 |
| 2025-05-15 | Bonney Michael WDirector | Option exercise M | +11,250 | 131.21 | 28,054 | Form 4 |
| 2025-05-08 | Bertozzi Carolyn RDirector | Grant or award A | +775 | – | 775 | Form 4 |
| 2025-05-08 | Sigal Charles ElliottDirector | Grant or award A | +775 | – | 775 | Form 4 |
| 2025-05-08 | Schulman Amy WDirector | Grant or award A | +775 | – | 11,961 | Form 4 |
| 2025-05-08 | Reitan Colleen FDirector | Grant or award A | +775 | – | 775 | Form 4 |
| 2025-05-08 | Pyott David e IDirector | Grant or award A | +775 | – | 911 | Form 4 |
| 2025-05-08 | Kellogg Peter NDirector | Grant or award A | +775 | – | 775 | Form 4 |
| 2025-05-08 | Hamburg Margaret ADirector | Grant or award A | +775 | – | 911 | Form 4 |
| 2025-05-08 | Brandicourt OlivierDirector | Grant or award A | +775 | – | 775 | Form 4 |
| 2025-05-08 | Bonney Michael WDirector | Grant or award A | +775 | – | 16,804 | Form 4 |
| 2025-05-08 | Ausiello Dennis ADirector | Grant or award A | +775 | – | 911 | Form 4 |
| 2025-05-02 | Greenstreet YvonneDirector, Chief Executive Officer | Gift G | −41,311 | – | 57,324 | Form 4 |
| 2025-03-24 | Pyott David e IDirector | Option exercise M | +7,440 | 88.95 | 7,576 | Form 4 |
| 2025-03-24 | Garg PushkalCMO & EVP Dev & Med Affairs | Option exercise M | +5,445 | 42.22 | 25,666 | Form 4 |
| 2025-03-13 | Schulman Amy WDirector | Option exercise M | +2,750 | 131.21 | 11,186 | Form 4 |
| 2025-03-03 | Greenstreet YvonneDirector, Chief Executive Officer | Grant or award A | +17,965 | – | 102,512 | Form 4 |
| 2025-03-03 | Poulton Jeffrey V.EVP, Chief Financial Officer | Grant or award A | +15,117 | – | 49,015 | Form 4 |
| 2025-03-03 | Garg PushkalCMO & EVP Dev & Med Affairs | Grant or award A | +14,137 | – | 27,099 | Form 4 |
| 2025-03-03 | Tanguler TolgaEVP, Chief Commercial Officer | Grant or award A | +14,137 | – | 28,482 | Form 4 |
| 2025-03-03 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Grant or award A | +3,871 | – | 16,256 | Form 4 |
| 2025-03-03 | Hesslein Robert W.EVP, CLO and Secretary | Grant or award A | +757 | – | 8,002 | Form 4 |
| 2025-02-27 | Garg PushkalCMO & EVP Dev & Med Affairs | Option exercise M | +1,908 | – | 13,897 | Form 4 |
| 2025-02-27 | Tanguler TolgaEVP, Chief Commercial Officer | Option exercise M | +1,667 | – | 14,858 | Form 4 |
| 2025-02-27 | Poulton Jeffrey V.EVP, Chief Financial Officer | Option exercise M | +1,908 | – | 34,694 | Form 4 |
| 2025-02-27 | Greenstreet YvonneDirector, Chief Executive Officer | Option exercise M | +5,921 | – | 87,447 | Form 4 |
| 2025-02-13 | Garg PushkalCMO & EVP Dev & Med Affairs | Grant or award A | +3,109 | – | 15,098 | Form 4 |
| 2025-02-13 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Grant or award A | +2,103 | – | 14,984 | Form 4 |
| 2025-02-13 | Poulton Jeffrey V.EVP, Chief Financial Officer | Grant or award A | +3,109 | – | 33,753 | Form 4 |
| 2025-02-13 | Greenstreet YvonneDirector, Chief Executive Officer | Grant or award A | +3,859 | – | 82,739 | Form 4 |
| 2025-01-27 | Garg PushkalCMO & EVP Dev & Med Affairs | Option exercise M | +23,876 | 88.95 | 39,581 | Form 4 |
| 2025-01-27 | Garg PushkalCMO & EVP Dev & Med Affairs | Option exercise M | +25,000 | 88.95 | 64,581 | Form 4 |
| 2025-01-23 | Sharp Phillip ADirector | Option exercise M | +11,250 | 131.21 | 11,250 | Form 4 |
| 2024-11-25 | Fitzgerald Kevin JosephCSO & EVP, Head of Research | Grant or award A | +3,000 | – | 15,881 | Form 4 |
| 2024-11-25 | Tanguler TolgaEVP, Chief Commercial Officer | Grant or award A | +3,000 | – | 14,660 | Form 4 |
| 2024-11-25 | Poulton Jeffrey V.EVP, Chief Financial Officer | Grant or award A | +3,434 | – | 32,326 | Form 4 |
| 2024-11-25 | Garg PushkalCMO & EVP Dev & Med Affairs | Grant or award A | +3,434 | – | 19,139 | Form 4 |
| 2024-11-25 | Greenstreet YvonneDirector, Chief Executive Officer | Grant or award A | +10,658 | – | 84,099 | Form 4 |
How to read it
- Buy, sale
- Code P and S on the form: shares bought or sold in the market, at the market price. The other codes are mostly pay (a grant, an option exercised) or tax (shares the company withheld), and say little about what the insider thinks of the price.
- Plan
- A sale or purchase under a Rule 10b5-1 plan, set up in advance and running on its own schedule. Since April 2023 the form has a box for it. Much executive selling is planned and says more about diversifying than about the company.
- Holds after
- The shares the insider still held after the trade, in the form the trade was in (directly, or indirectly through a trust or a fund).
- Value
- Shares times the price the form reports, which is often an average over several fills on the day.
Read from the SEC's own quarterly data sets of Forms 3, 4 and 5, and from each day's filings since the last one. A correcting amendment replaces the lines it restates. Every row links to its filing. None of this is advice: insiders sell for many reasons, and buy for fewer.