IONIS PHARMACEUTICALS INC (IONS)

Every figure below is the company's own, as filed. Nothing is estimated and nothing is smoothed — a period the filing does not support is left blank rather than drawn. Quarters are the company's own, counted from its financial year ending 12-31. Amounts in USD.

Revenue TTM

0 400M 800M 1.2B Q4 '09: 121.6M Q1 '10: 120M Q2 '10: 112.5M Q3 '10: 114.3M Q4 '10: 108.5M Q1 '11: 99.7M Q2 '11: 101M Q3 '11: 93.1M Q4 '11: 99.1M Q1 '12: 101.2M Q2 '12: 123.7M Q3 '12: 114.6M Q4 '12: 102M Q1 '13: 122.2M Q2 '13: 112.9M Q3 '13: 124.9M Q4 '13: 147.3M Q1 '14: 132.1M Q2 '14: 151.1M Q3 '14: 171.5M Q4 '14: 214.2M Q1 '15: 248.6M Q2 '15: 311.9M Q3 '15: 317M Q4 '15: 283.7M Q1 '16: 258M Q2 '16: 176M Q3 '16: 237.8M Q4 '16: 346.6M Q1 '17: 425.5M Q2 '17: 499.3M Q3 '17: 506.7M Q4 '17: 514.2M Q1 '18: 542.8M Q2 '18: 548.3M Q3 '18: 575.4M Q4 '18: 599.7M Q1 '19: 752.5M Q2 '19: 798.5M Q3 '19: 821M Q4 '19: 1.1B Q1 '20: 958.8M Q2 '20: 940.5M Q3 '20: 932.7M Q4 '20: 729.3M Q1 '21: 707.5M Q2 '21: 687.7M Q3 '21: 660.7M Q4 '21: 810.5M Q1 '22: 840.8M Q2 '22: 848.8M Q3 '22: 875.5M Q4 '22: 587.4M Q1 '23: 576M Q2 '23: 630.6M Q3 '23: 615M Q4 '23: 787.6M Q1 '24: 776.6M Q2 '24: 813.5M Q3 '24: 803.1M Q4 '24: 705.1M Q1 '25: 717.3M Q2 '25: 944.1M Q3 '25: 967M Q4 '25: 943.7M Q1 '26: 1.1B Q2 '26: 874.1M Q3 '10 Q4 '12 Q1 '15 Q2 '17 Q3 '19 Q4 '21 Q1 '24 Q2 '26

Gross Profit TTM

0 400M 800M 1.2B Q4 '18: 597.9M Q1 '19: 749.6M Q2 '19: 794.3M Q3 '19: 815.8M Q4 '19: 1.1B Q1 '20: 952.9M Q2 '20: 932.9M Q3 '20: 923M Q4 '20: 717.3M Q1 '21: 695.5M Q2 '21: 675.8M Q3 '21: 648.8M Q4 '21: 799.6M Q1 '22: 828.3M Q2 '22: 834.6M Q3 '22: 862.8M Q4 '22: 573.2M Q1 '23: 564.7M Q2 '23: 621.5M Q3 '23: 605.3M Q4 '23: 778.5M Q1 '24: 766.7M Q2 '24: 801.9M Q3 '24: 792.6M Q4 '24: 693.9M Q1 '25: 706.7M Q2 '25: 933.5M Q3 '25: 955.2M Q4 '25: 927.8M Q1 '26: 1B Q2 '26: 858.1M Q2 '19 Q2 '20 Q2 '21 Q2 '22 Q2 '23 Q2 '24 Q2 '25 Q2 '26

Revenue minus cost of sales. This filer tags no gross profit of its own..

Operating Income TTM

-750M -500M -250M 0 250M 500M 750M Q4 '09: -27.5M Q1 '10: -31.8M Q2 '10: -45.6M Q3 '10: -44.2M Q4 '10: -48.4M Q1 '11: -59.6M Q2 '11: -55M Q3 '11: -68.3M Q4 '11: -71.1M Q1 '12: -73.4M Q2 '12: -55.7M Q3 '12: -61.4M Q4 '12: -68.9M Q1 '13: -48.8M Q2 '13: -60.5M Q3 '13: -57.9M Q4 '13: -51.7M Q1 '14: -83M Q2 '14: -81.7M Q3 '14: -77.7M Q4 '14: -47.7M Q1 '15: -27.4M Q2 '15: 23.9M Q3 '15: -2.7M Q4 '15: -75.8M Q1 '16: -121.1M Q2 '16: -214.7M Q3 '16: -150.4M Q4 '16: -46.3M Q1 '17: 27.8M Q2 '17: 83.2M Q3 '17: 78.4M Q4 '17: 31M Q1 '18: 8.3M Q2 '18: -48.5M Q3 '18: -78.4M Q4 '18: -61.4M Q1 '19: 63.5M Q2 '19: 94.9M Q3 '19: 116M Q4 '19: 365.9M Q1 '20: 183.2M Q2 '20: 150.3M Q3 '20: 111.2M Q4 '20: -172.1M Q1 '21: -202.9M Q2 '21: -224.1M Q3 '21: -273.5M Q4 '21: -30.2M Q1 '22: 4.3M Q2 '22: -8.3M Q3 '22: 18.4M Q4 '22: -410.2M Q1 '23: -466.8M Q2 '23: -471.5M Q3 '23: -555.6M Q4 '23: -353.7M Q1 '24: -389.1M Q2 '24: -365M Q3 '24: -370.4M Q4 '24: -475.1M Q1 '25: -472.4M Q2 '25: -266.5M Q3 '25: -278M Q4 '25: -381.7M Q1 '26: -352.2M Q2 '26: -594.4M Q3 '10 Q4 '12 Q1 '15 Q2 '17 Q3 '19 Q4 '21 Q1 '24 Q2 '26

Net Income TTM

-750M -500M -250M 0 250M 500M 750M Q4 '10: -61.3M Q1 '11: -71.6M Q2 '11: -64.3M Q3 '11: -78.8M Q4 '11: -84.8M Q1 '12: -88.8M Q2 '12: -72.1M Q3 '12: -82.9M Q4 '12: -65.5M Q1 '13: -43.2M Q2 '13: -52.1M Q3 '13: -39M Q4 '13: -60.6M Q1 '14: -90.3M Q2 '14: -92.2M Q3 '14: -94.3M Q4 '14: -39M Q1 '15: -24.4M Q2 '15: 23.3M Q3 '15: 14.2M Q4 '15: -88.3M Q1 '16: -134.5M Q2 '16: -227M Q3 '16: -183.9M Q4 '16: -86.6M Q1 '17: -14.7M Q2 '17: 39.1M Q3 '17: 29.1M Q4 '17: 346K Q1 '18: -10M Q2 '18: -47.3M Q3 '18: -49.3M Q4 '18: 273.7M Q1 '19: 359.6M Q2 '19: 399.1M Q3 '19: 429.8M Q4 '19: 294.1M Q1 '20: 170.1M Q2 '20: 145.3M Q3 '20: 94.7M Q4 '20: -444.3M Q1 '21: -494.5M Q2 '21: -549.7M Q3 '21: -607.7M Q4 '21: -28.6M Q1 '22: -3.9M Q2 '22: -28.2M Q3 '22: 7.3M Q4 '22: -269.7M Q1 '23: -328.9M Q2 '23: -309M Q3 '23: -409.5M Q4 '23: -366.3M Q1 '24: -384.8M Q2 '24: -365.7M Q3 '24: -358.8M Q4 '24: -453.9M Q1 '25: -458M Q2 '25: -268.2M Q3 '25: -256.3M Q4 '25: -381.4M Q1 '26: -327M Q2 '26: -565.2M Q2 '12 Q2 '14 Q2 '16 Q2 '18 Q2 '20 Q2 '22 Q2 '24 Q2 '26

Cost of Revenue TTM

0 6M 12M 18M Q4 '18: 1.8M Q1 '19: 2.9M Q2 '19: 4.2M Q3 '19: 5.2M Q4 '19: 4.4M Q1 '20: 5.9M Q2 '20: 7.5M Q3 '20: 9.7M Q4 '20: 11.9M Q1 '21: 12M Q2 '21: 11.9M Q3 '21: 11.9M Q4 '21: 10.8M Q1 '22: 12.4M Q2 '22: 14.2M Q3 '22: 12.7M Q4 '22: 14.1M Q1 '23: 11.3M Q2 '23: 9.1M Q3 '23: 9.8M Q4 '23: 9.1M Q1 '24: 9.9M Q2 '24: 11.6M Q3 '24: 10.4M Q4 '24: 11.2M Q1 '25: 10.5M Q2 '25: 10.5M Q3 '25: 11.8M Q4 '25: 15.9M Q1 '26: 17.4M Q2 '26: 16M Q2 '19 Q2 '20 Q2 '21 Q2 '22 Q2 '23 Q2 '24 Q2 '25 Q2 '26

Operating Cash Flow TTM

-1.1B -700M -350M 0 350M 700M 1.1B Q2 '10: -80.3M Q3 '10: -69.5M Q4 '10: -63.6M Q1 '11: -81.7M Q2 '11: -113M Q3 '11: -114.7M Q4 '11: -114.8M Q1 '12: -81.7M Q2 '12: -58.1M Q3 '12: -59.8M Q4 '13: 63.5M Q1 '14: 41.7M Q2 '14: -15M Q3 '14: -78.9M Q4 '14: 6.3M Q1 '15: -4.2M Q2 '15: 95M Q3 '15: 129.3M Q4 '15: 21.1M Q1 '16: -11.8M Q2 '16: -110.8M Q3 '16: -122.7M Q4 '16: -112.1M Q1 '17: 86.3M Q2 '17: 122.5M Q3 '17: 126.9M Q4 '17: 174.1M Q1 '18: 64.6M Q2 '18: 562.5M Q3 '18: 507.8M Q4 '18: 602.9M Q1 '19: 697.4M Q2 '19: 170.1M Q3 '19: 183.3M Q4 '19: 345.6M Q1 '20: 230.3M Q2 '20: 213.2M Q3 '20: 215.8M Q4 '21: 30.8M Q1 '22: 53.8M Q2 '22: 98.4M Q3 '22: 129.5M Q4 '22: -274.4M Q1 '23: -376.7M Q2 '23: -456M Q3 '23: -540.6M Q4 '23: -307.5M Q1 '24: -323.5M Q2 '24: -346M Q3 '24: -351.9M Q4 '24: -500.9M Q1 '25: -501.8M Q2 '25: -230.6M Q3 '25: -247M Q4 '25: -268.6M Q1 '26: -910.6M Q2 '26: -496.4M Q2 '10 Q2 '12 Q2 '15 Q2 '17 Q2 '19 Q2 '22 Q2 '24 Q2 '26

Free Cash Flow TTM

-1.1B -700M -350M 0 350M 700M 1.1B Q2 '10: -95.4M Q3 '10: -83.9M Q4 '10: -76.8M Q1 '11: -86.5M Q2 '11: -120.3M Q3 '11: -124.1M Q4 '11: -125M Q1 '12: -89.4M Q2 '12: -63.2M Q3 '12: -62.1M Q4 '13: 61.9M Q1 '14: 39M Q2 '14: -19.1M Q3 '14: -83.3M Q4 '14: -1.2M Q1 '15: -11.2M Q2 '15: 86.7M Q3 '15: 120.5M Q4 '15: 13.4M Q1 '16: -19.3M Q2 '16: -117.8M Q3 '16: -129.5M Q4 '16: -119.2M Q1 '17: 76.6M Q2 '17: 109.2M Q3 '17: 97.6M Q4 '17: 139.4M Q1 '18: 30.8M Q2 '18: 528.2M Q3 '18: 487.3M Q4 '18: 589.3M Q1 '19: 683M Q2 '19: 158.2M Q3 '19: 158.8M Q4 '19: 314.7M Q1 '20: 193.6M Q2 '20: 171.4M Q3 '20: 178M Q4 '21: 18.8M Q1 '22: 40.9M Q2 '22: 86.5M Q3 '22: 115.4M Q4 '22: -290.1M Q1 '23: -400.2M Q2 '23: -488.1M Q3 '23: -569.3M Q4 '23: -331.3M Q1 '24: -341.3M Q2 '24: -358M Q3 '24: -370.9M Q4 '24: -546.2M Q1 '25: -555.1M Q2 '25: -290M Q3 '25: -302.7M Q4 '25: -320M Q1 '26: -971.3M Q2 '26: -560.8M Q2 '10 Q2 '12 Q2 '15 Q2 '17 Q2 '19 Q2 '22 Q2 '24 Q2 '26

Operating cash flow minus capital expenditure.

Shares Outstanding Quarterly

0 70M 140M 210M Q2 '09: 98.1M Q3 '09: 98.3M Q1 '10: 99M Q2 '10: 99.1M Q3 '10: 99.2M Q1 '11: 99.6M Q2 '11: 99.6M Q3 '11: 99.7M Q1 '12: 100.2M Q2 '12: 100.2M Q3 '12: 100.7M Q1 '13: 101.9M Q2 '13: 108.5M Q3 '13: 115.3M Q2 '14: 117.6M Q4 '14: 122.8M Q2 '15: 127.8M Q3 '15: 120M Q1 '16: 120.6M Q2 '16: 120.8M Q3 '16: 123.4M Q4 '16: 124M Q1 '17: 125M Q2 '17: 124M Q3 '17: 124.4M Q4 '17: 126.9M Q1 '18: 125.3M Q2 '18: 128.7M Q3 '18: 137.3M Q4 '18: 149.9M Q1 '19: 141.5M Q2 '19: 140.2M Q3 '19: 143.4M Q4 '19: 153.3M Q1 '20: 139.4M Q2 '20: 139.4M Q3 '20: 139.7M Q4 '20: 140M Q1 '21: 140.8M Q2 '21: 141M Q3 '21: 141.1M Q4 '21: 160.3M Q1 '22: 141.6M Q2 '22: 141.8M Q3 '22: 141.9M Q1 '23: 142.7M Q2 '23: 143.1M Q3 '23: 143.3M Q1 '24: 145.5M Q2 '24: 146M Q3 '24: 148.6M Q1 '25: 158.7M Q2 '25: 182.3M Q3 '25: 159.8M Q1 '26: 164.9M Q2 '26: 165.4M Q2 '11 Q3 '13 Q3 '16 Q2 '18 Q1 '20 Q4 '21 Q1 '24 Q2 '26

Weighted average diluted, as the filer reports it for each period. An average cannot be added across periods, so this one is always shown per period the filer tagged rather than as a trailing year.

EPS TTM

-4.50 -3.00 -1.50 0.00 1.50 3.00 4.50 Q4 '10: -0.62 Q1 '11: -0.72 Q2 '11: -0.65 Q3 '11: -0.79 Q4 '11: -0.85 Q1 '12: -0.89 Q2 '12: -0.72 Q3 '12: -0.82 Q4 '12: -0.65 Q1 '13: -0.43 Q2 '13: -0.51 Q3 '13: -0.35 Q4 '13: -0.53 Q1 '14: -0.78 Q2 '14: -0.79 Q3 '14: -0.81 Q4 '14: -0.35 Q1 '15: -0.22 Q2 '15: 0.17 Q3 '15: 0.10 Q4 '15: -0.74 Q1 '16: -1.12 Q2 '16: -1.88 Q3 '16: -1.52 Q4 '16: -0.72 Q1 '17: -0.13 Q2 '17: 0.32 Q3 '17: 0.24 Q4 '17: 0.00 Q1 '18: -0.08 Q2 '18: -0.35 Q3 '18: -0.36 Q4 '18: 1.88 Q1 '19: 2.51 Q2 '19: 2.79 Q3 '19: 3.00 Q4 '19: 2.07 Q1 '20: 1.17 Q2 '20: 1.00 Q3 '20: 0.64 Q4 '20: -3.18 Q1 '21: -3.54 Q2 '21: -3.93 Q3 '21: -4.33 Q4 '21: -0.38 Q1 '22: -0.20 Q2 '22: -0.37 Q3 '22: -0.12 Q4 '22: -1.90 Q1 '23: -2.31 Q2 '23: -2.17 Q3 '23: -2.87 Q4 '23: -2.56 Q1 '24: -2.67 Q2 '24: -2.52 Q3 '24: -2.44 Q4 '24: -3.04 Q1 '25: -2.99 Q2 '25: -1.84 Q3 '25: -1.69 Q4 '25: -2.44 Q1 '26: -2.07 Q2 '26: -3.46 Q2 '12 Q2 '14 Q2 '16 Q2 '18 Q2 '20 Q2 '22 Q2 '24 Q2 '26

The filer's own published earnings a share for each quarter, four quarters added up. The company page divides trailing net income by the share count instead, which lands within about 1% of this and is not the same sum, so the two are named differently rather than presented as one figure.