IONIS PHARMACEUTICALS INC (IONS)

Every figure below is the company's own, as filed. Nothing is estimated and nothing is smoothed — a period the filing does not support is left blank rather than drawn. Quarters are the company's own, counted from its financial year ending 12-31. Amounts in USD.

Revenue Quarterly

0 200M 400M 600M Q1 '09: 31.6M Q2 '09: 31M Q3 '09: 26.8M Q4 '09: 32.3M Q1 '10: 29.9M Q2 '10: 23.5M Q3 '10: 28.6M Q4 '10: 26.4M Q1 '11: 21.1M Q2 '11: 24.8M Q3 '11: 20.7M Q4 '11: 32.4M Q1 '12: 23.2M Q2 '12: 47.3M Q3 '12: 11.6M Q4 '12: 19.9M Q1 '13: 43.4M Q2 '13: 38.1M Q3 '13: 23.6M Q4 '13: 42.2M Q1 '14: 28.2M Q2 '14: 57.1M Q3 '14: 44.1M Q4 '14: 84.9M Q1 '15: 62.6M Q2 '15: 120.4M Q3 '15: 49.1M Q4 '15: 51.6M Q1 '16: 36.9M Q2 '16: 38.5M Q3 '16: 110.9M Q4 '16: 160.3M Q1 '17: 115.8M Q2 '17: 112.3M Q3 '17: 118.3M Q4 '17: 167.8M Q1 '18: 144.4M Q2 '18: 117.7M Q3 '18: 145.4M Q4 '18: 192.1M Q1 '19: 297.2M Q2 '19: 163.8M Q3 '19: 167.9M Q4 '19: 493.7M Q1 '20: 133.4M Q2 '20: 145.5M Q3 '20: 160.1M Q4 '20: 290.3M Q1 '21: 111.6M Q2 '21: 125.8M Q3 '21: 133.1M Q4 '21: 440M Q1 '22: 141.9M Q2 '22: 133.8M Q3 '22: 159.8M Q4 '22: 151.9M Q1 '23: 130.5M Q2 '23: 188.4M Q3 '23: 144.2M Q4 '23: 324.5M Q1 '24: 119.5M Q2 '24: 225.2M Q3 '24: 133.8M Q4 '24: 226.6M Q1 '25: 131.6M Q2 '25: 452M Q3 '25: 156.7M Q4 '25: 203.3M Q1 '26: 246.1M Q2 '26: 267.9M Q3 '10 Q4 '12 Q1 '15 Q2 '17 Q3 '19 Q4 '21 Q1 '24 Q2 '26

Gross Profit Quarterly

0 200M 400M 600M Q1 '18: 144.4M Q2 '18: 117.7M Q3 '18: 145.4M Q4 '18: 190.3M Q1 '19: 296.2M Q2 '19: 162.4M Q3 '19: 166.9M Q4 '19: 492.7M Q1 '20: 130.8M Q2 '20: 142.5M Q3 '20: 157M Q4 '20: 287M Q1 '21: 109M Q2 '21: 122.8M Q3 '21: 130M Q4 '21: 437.8M Q1 '22: 137.7M Q2 '22: 129M Q3 '22: 158.3M Q4 '22: 148.2M Q1 '23: 129.2M Q2 '23: 185.9M Q3 '23: 142M Q4 '23: 321.4M Q1 '24: 117.3M Q2 '24: 221.1M Q3 '24: 132.7M Q4 '24: 222.7M Q1 '25: 130.1M Q2 '25: 447.9M Q3 '25: 154.4M Q4 '25: 195.4M Q1 '26: 243.1M Q2 '26: 265.2M Q4 '18 Q1 '20 Q2 '21 Q3 '22 Q4 '23 Q1 '25 Q2 '26

Revenue minus cost of sales. This filer tags no gross profit of its own..

Operating Income Quarterly

-270M -180M -90M 0 90M 180M 270M Q1 '09: -642K Q2 '09: -4.8M Q3 '09: -10.4M Q4 '09: -11.7M Q1 '10: -4.9M Q2 '10: -18.7M Q3 '10: -8.9M Q4 '10: -15.9M Q1 '11: -16.1M Q2 '11: -14.1M Q3 '11: -22.3M Q4 '11: -18.6M Q1 '12: -18.5M Q2 '12: 3.7M Q3 '12: -28M Q4 '12: -26.1M Q1 '13: 1.6M Q2 '13: -7.9M Q3 '13: -25.5M Q4 '13: -19.9M Q1 '14: -29.7M Q2 '14: -6.7M Q3 '14: -21.5M Q4 '14: 10.1M Q1 '15: -9.3M Q2 '15: 44.6M Q3 '15: -48.1M Q4 '15: -62.9M Q1 '16: -54.7M Q2 '16: -48.9M Q3 '16: 16.1M Q4 '16: 41.2M Q1 '17: 19.5M Q2 '17: 6.5M Q3 '17: 11.3M Q4 '17: -6.2M Q1 '18: -3.3M Q2 '18: -50.3M Q3 '18: -18.6M Q4 '18: 10.8M Q1 '19: 121.5M Q2 '19: -18.8M Q3 '19: 2.5M Q4 '19: 260.7M Q1 '20: -61.1M Q2 '20: -51.8M Q3 '20: -36.5M Q4 '20: -22.7M Q1 '21: -92M Q2 '21: -73M Q3 '21: -85.8M Q4 '21: 220.6M Q1 '22: -57.5M Q2 '22: -85.5M Q3 '22: -59.2M Q4 '22: -208M Q1 '23: -114.1M Q2 '23: -90.2M Q3 '23: -143.3M Q4 '23: -6.1M Q1 '24: -149.5M Q2 '24: -66.1M Q3 '24: -148.7M Q4 '24: -110.8M Q1 '25: -146.9M Q2 '25: 139.8M Q3 '25: -160.2M Q4 '25: -214.5M Q1 '26: -117.4M Q2 '26: -102.3M Q3 '10 Q4 '12 Q1 '15 Q2 '17 Q3 '19 Q4 '21 Q1 '24 Q2 '26

Net Income Quarterly

-450M -300M -150M 0 150M 300M 450M Q2 '09: -2.7M Q3 '09: -11.6M Q1 '10: -9.7M Q2 '10: -25.2M Q3 '10: -12.5M Q4 '10: -14M Q1 '11: -20M Q2 '11: -17.9M Q3 '11: -26.9M Q4 '11: -20M Q1 '12: -24M Q2 '12: -1.2M Q3 '12: -37.6M Q4 '12: -2.6M Q1 '13: -1.7M Q2 '13: -10.1M Q3 '13: -24.6M Q4 '13: -24.3M Q1 '14: -31.3M Q2 '14: -12.1M Q3 '14: -26.7M Q4 '14: 31.1M Q1 '15: -16.7M Q2 '15: 35.6M Q3 '15: -35.8M Q4 '15: -71.4M Q1 '16: -62.9M Q2 '16: -56.9M Q3 '16: 7.4M Q4 '16: 25.9M Q1 '17: 9M Q2 '17: -3.1M Q3 '17: -2.6M Q4 '17: -2.9M Q1 '18: -1.4M Q2 '18: -40.4M Q3 '18: -4.6M Q4 '18: 320.1M Q1 '19: 84.4M Q2 '19: -876K Q3 '19: 26.2M Q4 '19: 184.4M Q1 '20: -39.6M Q2 '20: -25.6M Q3 '20: -24.5M Q4 '20: -354.5M Q1 '21: -89.9M Q2 '21: -80.9M Q3 '21: -82.5M Q4 '21: 224.6M Q1 '22: -65.2M Q2 '22: -105.1M Q3 '22: -47M Q4 '22: -52.4M Q1 '23: -124.3M Q2 '23: -85.3M Q3 '23: -147.4M Q4 '23: -9.3M Q1 '24: -142.8M Q2 '24: -66.3M Q3 '24: -140.5M Q4 '24: -104.3M Q1 '25: -146.9M Q2 '25: 123.6M Q3 '25: -128.6M Q4 '25: -229.4M Q1 '26: -92.5M Q2 '26: -114.6M Q3 '10 Q4 '12 Q1 '15 Q2 '17 Q3 '19 Q4 '21 Q1 '24 Q2 '26

Cost of Revenue Quarterly

0 3M 6M 9M Q1 '18: 0 Q2 '18: 0 Q3 '18: 0 Q4 '18: 1.8M Q1 '19: 1M Q2 '19: 1.4M Q3 '19: 967K Q4 '19: 1M Q1 '20: 2.5M Q2 '20: 3M Q3 '20: 3.1M Q4 '20: 3.3M Q1 '21: 2.6M Q2 '21: 3M Q3 '21: 3.1M Q4 '21: 2.2M Q1 '22: 4.2M Q2 '22: 4.7M Q3 '22: 1.5M Q4 '22: 3.7M Q1 '23: 1.3M Q2 '23: 2.5M Q3 '23: 2.2M Q4 '23: 3.1M Q1 '24: 2.2M Q2 '24: 4.2M Q3 '24: 1.1M Q4 '24: 3.8M Q1 '25: 1.5M Q2 '25: 4.2M Q3 '25: 2.3M Q4 '25: 8M Q1 '26: 3M Q2 '26: 2.7M Q4 '18 Q1 '20 Q2 '21 Q3 '22 Q4 '23 Q1 '25 Q2 '26

Operating Cash Flow Quarterly

-900M -600M -300M 0 300M 600M 900M Q3 '09: -32.3M Q4 '09: -31.4M Q1 '10: -21.7M Q2 '10: 5M Q3 '10: -21.4M Q4 '10: -25.5M Q1 '11: -39.8M Q2 '11: -26.2M Q3 '11: -23.2M Q4 '11: -25.6M Q1 '12: -6.7M Q2 '12: -2.6M Q3 '12: -24.9M Q1 '13: -10.6M Q2 '13: 22.7M Q3 '13: 65.8M Q4 '13: -14.5M Q1 '14: -32.3M Q2 '14: -34M Q3 '14: 1.9M Q4 '14: 70.7M Q1 '15: -42.8M Q2 '15: 65.2M Q3 '15: 36.2M Q4 '15: -37.5M Q1 '16: -75.8M Q2 '16: -33.8M Q3 '16: 24.3M Q4 '16: -26.8M Q1 '17: 122.7M Q2 '17: 2.4M Q3 '17: 28.7M Q4 '17: 20.4M Q1 '18: 13.2M Q2 '18: 500.2M Q3 '18: -26M Q4 '18: 115.5M Q1 '19: 107.7M Q2 '19: -27.1M Q3 '19: -12.8M Q4 '19: 277.8M Q1 '20: -7.6M Q2 '20: -44.2M Q3 '20: -10.3M Q1 '21: -54.7M Q2 '21: -62.7M Q3 '21: -55.6M Q4 '21: 203.7M Q1 '22: -31.6M Q2 '22: -18.1M Q3 '22: -24.4M Q4 '22: -200.2M Q1 '23: -134M Q2 '23: -97.4M Q3 '23: -109M Q4 '23: 32.9M Q1 '24: -149.9M Q2 '24: -119.9M Q3 '24: -115M Q4 '24: -116.1M Q1 '25: -150.8M Q2 '25: 151.3M Q3 '25: -131.4M Q4 '25: -137.7M Q1 '26: -792.8M Q2 '26: 565.5M Q1 '10 Q2 '12 Q4 '14 Q1 '17 Q2 '19 Q4 '21 Q1 '24 Q2 '26

Free Cash Flow Quarterly

-900M -600M -300M 0 300M 600M 900M Q3 '09: -33.7M Q4 '09: -33.1M Q1 '10: -32.7M Q2 '10: 4.1M Q3 '10: -22.3M Q4 '10: -26M Q1 '11: -42.4M Q2 '11: -29.6M Q3 '11: -26.1M Q4 '11: -26.9M Q1 '12: -6.8M Q2 '12: -3.3M Q3 '12: -25M Q1 '13: -10.8M Q2 '13: 22.4M Q3 '13: 65.3M Q4 '13: -14.9M Q1 '14: -33.7M Q2 '14: -35.7M Q3 '14: 1.1M Q4 '14: 67.1M Q1 '15: -43.7M Q2 '15: 62.1M Q3 '15: 34.9M Q4 '15: -39.9M Q1 '16: -76.4M Q2 '16: -36.4M Q3 '16: 23.2M Q4 '16: -29.6M Q1 '17: 119.4M Q2 '17: -3.9M Q3 '17: 11.7M Q4 '17: 12.1M Q1 '18: 10.8M Q2 '18: 493.6M Q3 '18: -29.2M Q4 '18: 114.1M Q1 '19: 104.5M Q2 '19: -31.1M Q3 '19: -28.7M Q4 '19: 270.1M Q1 '20: -16.7M Q2 '20: -53.3M Q3 '20: -22.1M Q1 '21: -56.4M Q2 '21: -67M Q3 '21: -58.9M Q4 '21: 201.2M Q1 '22: -34.4M Q2 '22: -21.4M Q3 '22: -30M Q4 '22: -204.3M Q1 '23: -144.5M Q2 '23: -109.4M Q3 '23: -111.2M Q4 '23: 32M Q1 '24: -154.4M Q2 '24: -126.1M Q3 '24: -124M Q4 '24: -141.6M Q1 '25: -163.4M Q2 '25: 139M Q3 '25: -136.7M Q4 '25: -159M Q1 '26: -814.6M Q2 '26: 549.5M Q1 '10 Q2 '12 Q4 '14 Q1 '17 Q2 '19 Q4 '21 Q1 '24 Q2 '26

Operating cash flow minus capital expenditure.

Shares Outstanding Quarterly

0 70M 140M 210M Q2 '09: 98.1M Q3 '09: 98.3M Q1 '10: 99M Q2 '10: 99.1M Q3 '10: 99.2M Q1 '11: 99.6M Q2 '11: 99.6M Q3 '11: 99.7M Q1 '12: 100.2M Q2 '12: 100.2M Q3 '12: 100.7M Q1 '13: 101.9M Q2 '13: 108.5M Q3 '13: 115.3M Q2 '14: 117.6M Q4 '14: 122.8M Q2 '15: 127.8M Q3 '15: 120M Q1 '16: 120.6M Q2 '16: 120.8M Q3 '16: 123.4M Q4 '16: 124M Q1 '17: 125M Q2 '17: 124M Q3 '17: 124.4M Q4 '17: 126.9M Q1 '18: 125.3M Q2 '18: 128.7M Q3 '18: 137.3M Q4 '18: 149.9M Q1 '19: 141.5M Q2 '19: 140.2M Q3 '19: 143.4M Q4 '19: 153.3M Q1 '20: 139.4M Q2 '20: 139.4M Q3 '20: 139.7M Q4 '20: 140M Q1 '21: 140.8M Q2 '21: 141M Q3 '21: 141.1M Q4 '21: 160.3M Q1 '22: 141.6M Q2 '22: 141.8M Q3 '22: 141.9M Q1 '23: 142.7M Q2 '23: 143.1M Q3 '23: 143.3M Q1 '24: 145.5M Q2 '24: 146M Q3 '24: 148.6M Q1 '25: 158.7M Q2 '25: 182.3M Q3 '25: 159.8M Q1 '26: 164.9M Q2 '26: 165.4M Q2 '11 Q3 '13 Q3 '16 Q2 '18 Q1 '20 Q4 '21 Q1 '24 Q2 '26

Weighted average diluted, as the filer reports it for each period. An average cannot be added across periods, so this one is always shown per period the filer tagged rather than as a trailing year.

EPS TTM

-4.50 -3.00 -1.50 0.00 1.50 3.00 4.50 Q4 '10: -0.62 Q1 '11: -0.72 Q2 '11: -0.65 Q3 '11: -0.79 Q4 '11: -0.85 Q1 '12: -0.89 Q2 '12: -0.72 Q3 '12: -0.82 Q4 '12: -0.65 Q1 '13: -0.43 Q2 '13: -0.51 Q3 '13: -0.35 Q4 '13: -0.53 Q1 '14: -0.78 Q2 '14: -0.79 Q3 '14: -0.81 Q4 '14: -0.35 Q1 '15: -0.22 Q2 '15: 0.17 Q3 '15: 0.10 Q4 '15: -0.74 Q1 '16: -1.12 Q2 '16: -1.88 Q3 '16: -1.52 Q4 '16: -0.72 Q1 '17: -0.13 Q2 '17: 0.32 Q3 '17: 0.24 Q4 '17: 0.00 Q1 '18: -0.08 Q2 '18: -0.35 Q3 '18: -0.36 Q4 '18: 1.88 Q1 '19: 2.51 Q2 '19: 2.79 Q3 '19: 3.00 Q4 '19: 2.07 Q1 '20: 1.17 Q2 '20: 1.00 Q3 '20: 0.64 Q4 '20: -3.18 Q1 '21: -3.54 Q2 '21: -3.93 Q3 '21: -4.33 Q4 '21: -0.38 Q1 '22: -0.20 Q2 '22: -0.37 Q3 '22: -0.12 Q4 '22: -1.90 Q1 '23: -2.31 Q2 '23: -2.17 Q3 '23: -2.87 Q4 '23: -2.56 Q1 '24: -2.67 Q2 '24: -2.52 Q3 '24: -2.44 Q4 '24: -3.04 Q1 '25: -2.99 Q2 '25: -1.84 Q3 '25: -1.69 Q4 '25: -2.44 Q1 '26: -2.07 Q2 '26: -3.46 Q2 '12 Q2 '14 Q2 '16 Q2 '18 Q2 '20 Q2 '22 Q2 '24 Q2 '26

The filer's own published earnings a share for each quarter, four quarters added up. The company page divides trailing net income by the share count instead, which lands within about 1% of this and is not the same sum, so the two are named differently rather than presented as one figure.